Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25420161.
- Also identified by DOI 10.1148/radiol.14142033.
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Abstract
Burgess et al ( 1 ) present intriguing results of repetitive transient opening of the blood-brain barrier (BBB) in a transgenic mouse model of advanced Alzheimer disease (AD). The results underscore the potential of using magnetic resonance (MR) imaging-guided focused ultrasound and microbubble ultrasonography (US) contrast agents for the disruption of the BBB as a potential long-term therapy to reduce amyloid plaque burden and improve cognitive performance. This daring conclusion that is based on an experimental animal model should now be confirmed in humans. Considering that the technology is commercially available and given the immense clinical need, clinical trials in this AD treatment should be initiated as soon as possible.
Medical subject headings
- Alzheimer Disease
- Blood-Brain Barrier
- Hippocampus
- Magnetic Resonance Imaging, Interventional
- Ultrasonic Therapy