Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 25431428.
- Also identified by DOI 10.1192/bjp.bp.113.142216 and PMC identifier 4312967.
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Abstract
N-methyl-d-aspartate receptor (NMDA-R) autoantibodies have been reported in people with acute psychosis. We hypothesised that their presence may be implicated in the aetiology of treatment-refractory psychosis. We sought to ascertain the point prevalence of NMDA-R antibody positivity in patients referred to services for treatment-refractory psychosis. We found that 3 (7.0%) of 43 individuals had low positive NMDA-R antibody titres. This suggests that NMDA-R autoantibodies are unlikely to account for a large proportion of treatment-refractory psychosis.
Medical subject headings
- Autoantibodies
- Drug Resistance
- Psychotic Disorders
- Receptors, N-Methyl-D-Aspartate