Mammalian-microbial cometabolism of L-carnitine in the context of atherosclerosis.
Where this comes from
- Record sourced from PubMed, PMID 25440049.
- Also identified by DOI 10.1016/j.cmet.2014.10.014.
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Abstract
γ-butyrobetaine has long been known as the precursor of endogenous L-carnitine synthesis. In this issue, Koeth et al. (2014) demonstrate that it is also a major metabolite of L-carnitine degradation by gut bacteria that precedes the enteric production of trimethylamine and trimethylamine-N-oxide.
Medical subject headings
- Atherosclerosis
- Betaine
- Carnitine
- Gastrointestinal Tract
- Methylamines