C16:0-ceramide signals insulin resistance.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25440051.
- Also identified by DOI 10.1016/j.cmet.2014.10.017 and PMC identifier 4393079.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
A substantive literature has accumulated implicating sphingolipids, in particular ceramides, as mediators of insulin resistance in metabolic syndrome. Thanks to recent technical advances in mouse genetics and lipidomics, two independent laboratories identify the same sphingolipid, C16:0-ceramide, as principal mediator of obesity-related insulin resistance (Turpin et al., 2014; Raichur et al., 2014).
Medical subject headings
- Ceramides
- Diet, High-Fat
- Glucose Intolerance
- Insulin Resistance
- Sphingosine N-Acyltransferase