Linking DNA damage, NAD(+)/SIRT1, and aging.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25440052.
- Also identified by DOI 10.1016/j.cmet.2014.10.015.
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Abstract
Diseases due to DNA damage repair machinery defects can resemble premature aging. In this issue of Cell Metabolism, Scheibye-Knudsen et al. (2014) demonstrate that increasing NAD(+) levels may reverse the inactivation of Sirt1 and mitochondrial defects in Cockayne Syndrome B that stem from nuclear NAD(+) depletion by the DNA repair protein PARP.
Medical subject headings
- Aging, Premature
- Cockayne Syndrome
- Diet, High-Fat
- NAD
- Sirtuin 1