Gram-positive antimicrobial activity of amino acid-based hydrogels.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25447243.
- Also identified by DOI 10.1002/adma.201403339.
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Abstract
Antimicrobial hydrogels are prepared based on the co-assembly of commercial Fmoc-phenylalanine and Fmoc-leucine, which act as the hydrogelator and antimicrobial building block, respectively. This co-assembled antimicrobial hydrogel is demonstrated to exhibit selective bactericidal activity for gram-positive bacteria while being biocompatible with normal mammalian cells, showing great potential as an antimicrobial coating for clinical anti-infective applications.
Medical subject headings
- Amino Acids
- Anti-Bacterial Agents
- Gram-Positive Bacteria
- Hydrogels