Identifying statin-associated autoimmune necrotizing myopathy.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25452351.
- Also identified by DOI 10.3949/ccjm.81a.13158.
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Abstract
Statins up-regulate expression of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR), the rate-limiting enzyme in cholesterol synthesis and the major target of autoantibodies in statin-associated immune-mediated necrotizing myopathy. As muscle cells regenerate, they express high levels of HMGCR, which may sustain the immune response even after statin therapy is stopped. Awareness of this entity will help physicians who prescribe statins to take action to limit the associated morbidity.
Medical subject headings
- Autoimmune Diseases
- Hydroxymethylglutaryl CoA Reductases
- Hydroxymethylglutaryl-CoA Reductase Inhibitors
- Muscular Diseases