A new biology of diabetes revealed by leptin.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25456738.
- Also identified by DOI 10.1016/j.cmet.2014.10.011.
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Abstract
A variety of leptin actions require a re-examination of classic concepts of metabolic diseases. Here we present evidence for two physiologic pathways: a pathway that protects nonadipose tissues from overaccumulation of potentially toxic lipids and unrecognized paracrine interactions between α and β cells revealed by leptin's ability to suppress diabetic hyperglucagonemia. These observations strongly point to new therapeutic possibilities for both type 1 and type 2 diabetes.
Medical subject headings
- Diabetes Mellitus
- Leptin