Topical versus intravenous tranexamic acid in total knee arthroplasty.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 25458092.
- Also identified by DOI 10.1016/j.arth.2014.10.007.
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Abstract
The objective of this study is to compare the effectiveness of intravenous versus topical application of tranexamic acid in patients undergoing knee arthroplasty. All patients who underwent primary knee arthroplasty at our total joint center over a 12-month period were included in the study. One surgeon utilized 1 g of IV TXA at time of incision in all patients (n=373) except those with a documented history of venous thromboembolism (VTE). Two surgeons utilized a topical application of TXA for all patients without exception (n=198) in which the joint was injected after capsular closure with 3 g TXA/100 mL saline. The transfusion rate was 0% in the topical group vs. 2.4% in the IV group and this was statistically significant (P<0.05).
Medical subject headings
- Antifibrinolytic Agents
- Arthroplasty, Replacement, Knee
- Blood Loss, Surgical
- Postoperative Hemorrhage
- Tranexamic Acid
Anatomy
- knee