Antiviral interferon-beta signaling induced by designed transcription activator-like effectors (TALE).
basic_science · Level V
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- Record sourced from PubMed, PMID 25470486.
- Also identified by DOI 10.1371/journal.pone.0114288 and PMC identifier PMC3732459.
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Abstract
Here we show that designed transcription activator-like effectors (TALEs) that bind to defined areas of the interferon beta promoter are capable to induce IFN-beta expression and signaling in human cells. Importantly, TALE-mediated IFN-beta signaling occurs independently of pathogen pattern recognition but effectively prohibits viral RNA replication as demonstrated with a hepatitis C virus replicon. TALEs were thus indicated to be valuable tools in various applications addressing, for example, virus-host interactions.