Enteroendocrine MC4R and energy balance: linking the long and the short of it.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25470541.
- Also identified by DOI 10.1016/j.cmet.2014.11.014.
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Abstract
Central MC4R pathways are well established as integrators of peripheral signals in the control of energy balance. In this issue, Panaro et al. (2014) identify that MC4Rs expressed on intestinal enteroendocrine L cells regulate PYY and GLP-1 secretion, two gut hormones implicated in the regulation of energy and glucose homeostasis.
Medical subject headings
- Enteroendocrine Cells
- Glucagon-Like Peptide 1
- Peptide YY
- Receptor, Melanocortin, Type 4