Betatrophin--promises fading and lessons learned.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25470542.
- Also identified by DOI 10.1016/j.cmet.2014.11.016 and PMC identifier 4410809.
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Abstract
The discovery of a potent mitogen for insulin-producing pancreatic β cells, optimistically termed "betatrophin," excited researchers and laypeople alike, promising a new therapeutic approach to diabetes. A recent "Matters Arising" report by Gusarova and colleagues (2014) places serious doubts on whether "betatrophin" plays any major role in β cell replication.
Medical subject headings
- Angiopoietins
- Insulin-Secreting Cells