A multitheragnostic nanobubble system to induce blood-brain barrier disruption with magnetically guided focused ultrasound.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25472627.
- Also identified by DOI 10.1002/adma.201403889.
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Abstract
A novel magnetically guidable nanobubble is designed for disrupting the blood-brain barrier (BBB) by combining magnetic guidance with focused ultrasound in vivo. The magnetic-nanobubble platform also demonstrates the potential to serve as a unique theranostic tool via performing focused ultrasound (FUS)-induced BBB disruption and magnetic resonance imaging (MRI)/ultrasound dual-modality contrast-agent imaging to improve the drug delivery of therapeutic substances or gene therapy into the central nervous system.
Medical subject headings
- Blood-Brain Barrier
- Magnetic Phenomena
- Nanoparticles
- Ultrasonics