Principled compassion.

Abstract

Investigational drugs can save or extend lives, and seriously ill patients not able to take part in clinical trials should have access to such drugs whenever possible. In a climate of increased public pressure for this access - often termed compassionate use - five states in the US have passed so-called ‘right to try’ legislation. These laws are ill advised, as they are not likely to substantially increase access and have the potential to compromise the clinical trial system.