An epigenetic therapy for diffuse intrinsic pontine gliomas.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25473916.
- Also identified by DOI 10.1038/nm.3769.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Diffuse intrinsic pontine glioma is a uniformly lethal malignant tumor of infancy with no effective therapies. A new study reveals that inhibition of JMJD3 has robust antitumor activity in diffuse intrinsic pontine glioma xenografts.
Medical subject headings
- Apoptosis
- Benzazepines
- Brain Stem Neoplasms
- Cell Proliferation
- Gene Expression Regulation, Neoplastic
- Glioma
- Histones
- Jumonji Domain-Containing Histone Demethylases
- Pyrimidines