MicroRNA-124 modulates social behavior in frontotemporal dementia.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25473917.
- Also identified by DOI 10.1038/nm.3768.
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Abstract
Frontotemporal dementia (FTD) is a neurodegenerative disease that causes social dysfunction and other symptoms. A new study suggests that social dysfunction in FTD is due to decreased microRNA-124 expression and resulting changes in glutamate receptor composition in the prefrontal cortex.
Medical subject headings
- Behavior, Animal
- Endosomal Sorting Complexes Required for Transport
- Frontal Lobe
- Frontotemporal Dementia
- MicroRNAs
- Nerve Tissue Proteins
- Neurons
- Receptors, AMPA
- Social Behavior