MicroRNAs: new players in IBD.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25475103.
- Also identified by DOI 10.1136/gutjnl-2014-307891 and PMC identifier 4345829.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
MicroRNAs (miRNAs) are small non-coding RNAs, 18-23 nucleotides long, which act as post-transcriptional regulators of gene expression. miRNAs are strongly implicated in the pathogenesis of many common diseases, including IBDs. This review aims to outline the history, biogenesis and regulation of miRNAs. The role of miRNAs in the development and regulation of the innate and adaptive immune system is discussed, with a particular focus on mechanisms pertinent to IBD and the potential translational applications.
Medical subject headings
- Inflammatory Bowel Diseases
- MicroRNAs