MTM-6, a phosphoinositide phosphatase, is required to promote synapse formation in Caenorhabditis elegans.
basic_science · Level V
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- Record sourced from PubMed, PMID 25479419.
- Also identified by DOI 10.1371/journal.pone.0114501 and PMC identifier PMC3846605.
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Abstract
Forming the proper number of synapses is crucial for normal neuronal development. We found that loss of function of the phosphoinositide phosphatase mtm-6 results in a reduction in the number of synaptic puncta. The reduction in synapses is partially the result of MTM-6 regulation of the secretion of the Wnt ligand EGL-20 from cells in the tail and partially the result of neuronal action. MTM-6 shows relative specificity for EGL-20 over the other Wnt ligands. We suggest that the ability of MTM-6 to regulate EGL-20 secretion is a function of its expression pattern. We conclude that regulation of secretion of different Wnt ligands can use different components. Additionally, we present a novel neuronal function for MTM-6.