Sleeping beauty wakes up the clonal succession model for homeostatic hematopoiesis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25479744.
- Also identified by DOI 10.1016/j.stem.2014.11.015.
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Abstract
Recently in Nature, Sun et al. (2014) used a sleeping beauty transposon system to demonstrate that natural hematopoiesis is sustained by the successive recruitment of thousands of clones that are mostly lineage restricted. These findings call into question whether homeostatic hematopoiesis is sustained by hematopoietic stem cells traditionally identified by transplantation.
Medical subject headings
- Cell Lineage
- Clone Cells
- Hematopoiesis