A split personality for nucleosomes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25480289.
- Also identified by DOI 10.1016/j.cell.2014.11.030.
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Abstract
A high-resolution look at where histones touch DNA reveals a surprisingly intricate, dynamic, and modular nucleosome. Three advances in the study by Rhee et al. include unexpected interactions between the H3 tail and linker DNA, new evidence for existence of subnucleosomal particles, and asymmetric patterns of histone modification within a single nucleosome that correspond to the direction of transcription.
Medical subject headings
- Nucleosomes
- Saccharomyces cerevisiae
- Transcription, Genetic