X-ray-induced shortwave infrared biomedical imaging using rare-earth nanoprobes.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25485705.
- Also identified by DOI 10.1021/nl504123r and PMC identifier 4296927.
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Abstract
Shortwave infrared (SWIR or NIR-II) light provides significant advantages for imaging biological structures due to reduced autofluorescence and photon scattering. Here, we report on the development of rare-earth nanoprobes that exhibit SWIR luminescence following X-ray irradiation. We demonstrate the ability of X-ray-induced SWIR luminescence (X-IR) to monitor biodistribution and map lymphatic drainage. Our results indicate X-IR imaging is a promising new modality for preclinical applications and has potential for dual-modality molecular disease imaging.
Medical subject headings
- Contrast Media
- Luminescence
- Lymphatic System
- Metals, Rare Earth
- Nanostructures
- Whole Body Imaging