Genetics and causality of triglyceride-rich lipoproteins in atherosclerotic cardiovascular disease.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25500239.
- Also identified by DOI 10.1016/j.jacc.2014.09.042.
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Abstract
Triglycerides represent 1 component of a heterogeneous pool of triglyceride-rich lipoproteins (TGRLs). The reliance on triglycerides or TGRLs as cardiovascular disease (CVD) risk biomarkers prompted investigations into therapies that lower plasma triglycerides as a means to reduce CVD events. Genetic studies identified TGRL components and pathways involved in their synthesis and metabolism. We advocate that only a subset of genetic mechanisms regulating TGRLs contribute to the risk of CVD events. This "omic" approach recently resulted in new targets for reducing CVD events.
Medical subject headings
- Atherosclerosis
- Cardiovascular Diseases
- Lipoproteins
- Triglycerides