An imagable and photothermal "Abraxane-like" nanodrug for combination cancer therapy to treat subcutaneous and metastatic breast tumors.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25504416.
- Also identified by DOI 10.1002/adma.201404308.
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Abstract
A new "Abraxane-like" nanotheranostic formulation self-assembled from three clinically approved agents, human serum albumin, paclitaxel, and indocyanine green, is developed. Utilizing such a newly formulated nanodrug, combined photothermal and chemotherapy is conducted under the guidance of imaging, not only effectively eliminating subcutaneous tumors, but also significantly inhibiting the development of metastatic tumors in this proof-of-concept study.
Medical subject headings
- Breast Neoplasms
- Nanoparticles
- Paclitaxel
- Phototherapy
- Subcutaneous Tissue