Furin-mediated sequential delivery of anticancer cytokine and small-molecule drug shuttled by graphene.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25504623.
- Also identified by DOI 10.1002/adma.201404498 and PMC identifier 5769919.
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Abstract
A cellular protease (furin)-mediated graphene-based nanosystem is developed for co-delivery of a membrane-associated cytokine (tumor-necrosis-factor-related apoptosis-inducing ligand, TRAIL) and an intracellular-acting small-molecule drug (Doxorubicin, DOX). TRAIL and DOX can be sequentially released toward the plasma membrane and nucleus, respectively.
Medical subject headings
- Antineoplastic Combined Chemotherapy Protocols
- Furin
- Graphite
- Nanocapsules
- Neoplasms, Experimental
- Peptides