diXa: a data infrastructure for chemical safety assessment.
Where this comes from
- Record sourced from PubMed, PMID 25505093.
- Also identified by DOI 10.1093/bioinformatics/btu827 and PMC identifier 4410652.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The field of toxicogenomics (the application of '-omics' technologies to risk assessment of compound toxicities) has expanded in the last decade, partly driven by new legislation, aimed at reducing animal testing in chemical risk assessment but mainly as a result of a paradigm change in toxicology towards the use and integration of genome wide data. Many research groups worldwide have generated large amounts of such toxicogenomics data. However, there is no centralized repository for archiving and making these data and associated tools for their analysis easily available. The Data Infrastructure for Chemical Safety Assessment (diXa) is a robust and sustainable infrastructure storing toxicogenomics data. A central data warehouse is connected to a portal with links to chemical information and molecular and phenotype data. diXa is publicly available through a user-friendly web interface. New data can be readily deposited into diXa using guidelines and templates available online. Analysis descriptions and tools for interrogating the data are available via the diXa portal. http://www.dixa-fp7.eu d.hendrickx@maastrichtuniversity.nl; info@dixa-fp7.eu Supplementary data are available at Bioinformatics online.
Medical subject headings
- Databases, Chemical
- Toxicogenetics