Gene-ectomy: gene ablation with CRISPR/Cas9 in human hematopoietic cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25517457.
- Also identified by DOI 10.1016/j.stem.2014.10.014.
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Abstract
CRISPR/Cas9 has recently been introduced as a gene editing tool and shows considerable promise. In this issue of Cell Stem Cell, Mandal et al. (2014) show efficient CRISPR/Cas9-mediated ablation of the CCR5 and B2M genes in primary human hematopoietic cells, two editing strategies that are potentially translatable into clinical application.
Medical subject headings
- CRISPR-Associated Proteins
- Clustered Regularly Interspaced Short Palindromic Repeats
- Gene Deletion
- Hematopoietic Stem Cells