Human somatic cell reprogramming: does the egg know best?

Colman, Alan; Burley, Justine · Cell Stem Cell · 2014

editorial · Level V

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Abstract

Somatic cell nuclear transfer offers an alternative approach to the use of exogenous transcription factors for the reprogramming of somatic cells. But is it a better way? Two groups have performed detailed molecular comparisons between human cell lines made by the two methods and report different conclusions.

Medical subject headings