Spatially gradated hydrogel platform as a 3D engineered tumor microenvironment.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25521283.
- Also identified by DOI 10.1002/adma.201404896.
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Abstract
There is an acute need for biomaterial tools that recreate the heterogeneous brain-tumor microenvironment. A microfluidic mixing tool is reported to encapsulate glioblastoma multiforme cells within miniaturized gelatin hydrogels containing overlapping patterns of tumor-inspired matrix signals. This approach permits in situ analysis of glioma cells at the molecular and genomic level as well as the potential for clinical insight.
Medical subject headings
- Hydrogels
- Tissue Engineering
- Tumor Microenvironment