Triggering of RNA interference with RNA-RNA, RNA-DNA, and DNA-RNA nanoparticles.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25521794.
- Also identified by DOI 10.1021/nn504508s and PMC identifier 4310632.
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Abstract
Control over cellular delivery of different functionalities and their synchronized activation is a challenging task. We report several RNA and RNA/DNA-based nanoparticles designed to conditionally activate the RNA interference in various human cells. These nanoparticles allow precise control over their formulation, stability in blood serum, and activation of multiple functionalities. Importantly, interferon and pro-inflammatory cytokine activation assays indicate the significantly lower responses for DNA nanoparticles compared to the RNA counterparts, suggesting greater potential of these molecules for therapeutic use.
Medical subject headings
- DNA
- Drug Carriers
- Nanoparticles
- RNA
- RNA Interference