Super-enhancer transcription converges on AID.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25525869.
- Also identified by DOI 10.1016/j.cell.2014.12.007.
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Abstract
AID mis-targeting is poorly understood but contributes significantly to B cell genome instability. Two new papers in Cell reveal that AID mistargeting occurs primarily in gene bodies within a nuclear microenvironment characterized by high levels of transcriptional activity, interconnected transcriptional regulatory elements, and overlapping sense and antisense (convergent) transcription.