Bladder cancer screening in aluminum smelter workers.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 25525927.
- Also identified by DOI 10.1097/JOM.0000000000000377 and PMC identifier 4374722.
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Abstract
To present results of a bladder cancer screening program conducted in 18 aluminum smelters in the United States from January 2000 to December 2010. Data were collected on a cohort of workers with a history of working in coal tar pitch volatile exposed areas including urine analysis for conventional cytology and ImmunoCyt/uCyt+ assay. ImmunoCyt/uCyt+ and cytology in combination showed a sensitivity of 62.30%, a specificity of 92.60%, a negative predictive value of 99.90%, and a positive predictive value of 2.96%. Fourteen cases of bladder cancer were detected, and the standardized incidence ratio of bladder cancer was 1.18 (95% confidence interval, 0.65 to 1.99). Individuals who tested positive on either test who were later determined to be cancer free had undergone expensive and invasive tests. Evidence to support continued surveillance of this cohort has not been demonstrated.
Medical subject headings
- Aluminum
- Early Detection of Cancer
- Metallurgy
- Occupational Diseases
- Urinary Bladder Neoplasms