Tunable rigidity of (polymeric core)-(lipid shell) nanoparticles for regulated cellular uptake.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25529120.
- Also identified by DOI 10.1002/adma.201404788.
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Abstract
Core-shell nanoparticles (NPs) with lipid shells and varying water content and rigidity but with the same chemical composition, size, and surface properties are assembled using a microfluidic platform. Rigidity can dramatically alter the cellular uptake efficiency, with more-rigid NPs able to pass more easily through cell membranes. The mechanism accounting for this rigidity-dependent cellular uptake is revealed through atomistic-level simulations.
Medical subject headings
- Lactic Acid
- Lipids
- Mechanical Phenomena
- Nanoparticles
- Polyglycolic Acid