Science to practice: can decreased lymph node MR imaging signal intensity be used as a biomarker for the efficacy of cancer vaccination?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25531469.
- Also identified by DOI 10.1148/radiol.14142331 and PMC identifier 4336745.
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Abstract
Summary In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.
Medical subject headings
- Adenocarcinoma
- Antigens
- Cell Movement
- Dendritic Cells
- Magnetic Resonance Imaging
- Pancreatic Neoplasms