Modelling bladder cancer in mice: opportunities and challenges.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 25533675.
- Also identified by DOI 10.1038/nrc3858 and PMC identifier 4386904.
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Abstract
The prognosis and treatment of bladder cancer have improved little in the past 20 years. Bladder cancer remains a debilitating and often fatal disease, and is among the most costly cancers to treat. The generation of informative mouse models has the potential to improve our understanding of bladder cancer progression, as well as to affect its diagnosis and treatment. However, relatively few mouse models of bladder cancer have been described, and in particular, few that develop invasive cancer phenotypes. This Review focuses on opportunities for improving the landscape of mouse models of bladder cancer.
Medical subject headings
- Disease Models, Animal
- Urinary Bladder Neoplasms