Graphene oxide-BaGdF5 nanocomposites for multi-modal imaging and photothermal therapy.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25542794.
- Also identified by DOI 10.1016/j.biomaterials.2014.11.055.
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Abstract
By using a solvothermal method in the presence of polyethylene glycol (PEG), BaGdF5 nanoparticles are firmly attached on the surface of graphene oxide (GO) nanosheets to form the GO/BaGdF5/PEG nanocomposites. The resulting GO/BaGdF5/PEG shows low cytotoxicity, positive magnetic resonance (MR) contrast effect and better X-ray attenuation property than Iohexol, which enables effective dual-modality MR and X-ray computed tomography (CT) imaging of the tumor model in vivo. The enhanced near-infrared absorbance, good photothermal stability and efficient tumor passive targeting of GO/BaGdF5/PEG result in the highly efficient photothermal ablation of tumor in vivo after intravenous injection of GO/BaGdF5/PEG and the following 808-nm laser irradiation (0.5 W/cm(2)). The histological and biochemical analysis data reveal no perceptible toxicity of GO/BaGdF5/PEG in mice after treatment. These results indicate potential application of GO/BaGdF5/PEG in dual-modality MR/CT imaging and photothermal therapy of cancers.
Medical subject headings
- Barium
- Fluorides
- Graphite
- Hyperthermia, Induced
- Multimodal Imaging
- Nanocomposites
- Oxides
- Phototherapy