Bioactive DNA-peptide nanotubes enhance the differentiation of neural stem cells into neurons.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25546084.
- Also identified by DOI 10.1021/nl504079q and PMC identifier 4296924.
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Abstract
We report the construction of DNA nanotubes covalently functionalized with the cell adhesion peptide RGDS as a bioactive substrate for neural stem cell differentiation. Alteration of the Watson-Crick base pairing program that builds the nanostructures allowed us to probe independently the effect of nanotube architecture and peptide bioactivity on stem cell differentiation. We found that both factors instruct synergistically the preferential differentiation of the cells into neurons rather than astrocytes.
Medical subject headings
- Cell Differentiation
- DNA
- Nanotubes, Peptide
- Neural Stem Cells
- Neurons
- Oligopeptides