Essential role for oxidative phosphorylation in cancer progression.
Level V
Where this comes from
- Record sourced from PubMed, PMID 25565201.
- Also identified by DOI 10.1016/j.cmet.2014.12.013.
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Abstract
Cancers are often affected by derangements in mitochondrial (mt) function, as well as mtDNA mutations. In this issue, Tan et al. (2015) demonstrate that only mtDNA-depleted cancer cells capable of recovering mtDNA from the host form metastasizing cancers in vivo, revealing an essential requirement for oxidative phosphorylation in tumor progression.
Medical subject headings
- Mitochondria