The anisotropic network model web server at 2015 (ANM 2.0).
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25568280.
- Also identified by DOI 10.1093/bioinformatics/btu847 and PMC identifier 4410662.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The anisotropic network model (ANM) is one of the simplest yet powerful tools for exploring protein dynamics. Its main utility is to predict and visualize the collective motions of large complexes and assemblies near their equilibrium structures. The ANM server, introduced by us in 2006 helped making this tool more accessible to non-sophisticated users. We now provide a new version (ANM 2.0), which allows inclusion of nucleic acids and ligands in the network model and thus enables the investigation of the collective motions of protein-DNA/RNA and -ligand systems. The new version offers the flexibility of defining the system nodes and the interaction types and cutoffs. It also includes extensive improvements in hardware, software and graphical interfaces. ANM 2.0 is available at http://anm.csb.pitt.edu eran.eyal@sheba.health.gov.il, eyal.eran@gmail.com.
Medical subject headings
- Proteins
- Software