A genome-wide association study of marginal zone lymphoma shows association to the HLA region.
other · Level V
Where this comes from
- Record sourced from PubMed, PMID 25569183.
- Also identified by DOI 10.1038/ncomms6751 and PMC identifier 4287989.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P=3.95 × 10(-15)) and HLA-B (rs2922994, P=2.43 × 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Medical subject headings
- Lymphoma, B-Cell, Marginal Zone
- Major Histocompatibility Complex
- Membrane Glycoproteins
- Polymorphism, Single Nucleotide
- White People