Diagnosis of neuroinvasive astrovirus infection in an immunocompromised adult with encephalitis by unbiased next-generation sequencing.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 25572898.
- Also identified by DOI 10.1093/cid/ciu912 and PMC identifier 4345816.
- Licence recorded as CC BY-NC-ND.
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Abstract
Metagenomic next-generation sequencing (NGS) was used to diagnose an unusual and fatal case of progressive encephalitis in an immunocompromised adult presenting at disease onset as bilateral hearing loss. The sequencing and confirmatory studies revealed neuroinvasive infection of the brain by an astrovirus belonging to a recently discovered VA/HMO clade.
Medical subject headings
- Astroviridae Infections
- Encephalitis, Viral
- Mamastrovirus