Unraveling the TWIST between EMT and cancer stemness.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25575073.
- Also identified by DOI 10.1016/j.stem.2014.12.005.
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Abstract
Twist1 has a well-established role in inducing Epithelial-Mesenchymal Transition (EMT) to promote tumor invasion and metastasis and can also inhibit apoptosis and confer stemness. In this issue of Cell Stem Cell, Beck et al. (2015) now show that low levels of Twist1 are essential for tumor initiation, maintenance, and stemness independent of its EMT-inducing activity.
Medical subject headings
- Carcinogenesis
- Disease Progression
- Neoplastic Stem Cells
- Nuclear Proteins
- Skin Neoplasms
- Twist-Related Protein 1