Targeting the cellular origin of organ fibrosis.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25575074.
- Also identified by DOI 10.1016/j.stem.2014.12.008.
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Abstract
Organ fibrosis after injury, which can significantly compromise tissue function, is in part due to proliferation of fibroblasts and myofibroblasts of unclear cellular origin. Now in Cell Stem Cell, Kramann et al. (2015) show that perivascular Gli1+ mesenchymal-stem-cell-like cells generate a large fraction of myofibroblasts in disease conditions.
Medical subject headings
- Fibrosis
- Kruppel-Like Transcription Factors