Waddington's valleys and Captain Cook's islands.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25575076.
- Also identified by DOI 10.1016/j.stem.2014.12.009.
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Abstract
Somatic reprogramming has relied heavily on theoretical models that view differentiation in terms of developmental branch point decisions. Recent studies in Cell now reveal a dominant role of the microenvironment in shaping epigenetic identity of macrophages, thus providing support for alternative models of cell fate acquisition.