F-class cells: new routes and destinations for induced pluripotency.
basic_science · Level V
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- Record sourced from PubMed, PMID 25575077.
- Also identified by DOI 10.1016/j.stem.2014.12.007.
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Abstract
A series of five related publications describe an alternative pluripotent state that is dependent on continuous high levels of exogenous reprogramming factor expression. A comprehensive effort to molecularly compare the acquisition of this state to induced pluripotency aims at providing new insights into the mechanisms underlying cellular reprogramming.