Clonal evolution in cancer: a tale of twisted twines.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 25575078.
- Also identified by DOI 10.1016/j.stem.2014.12.011.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Intra-tumor heterogeneity of cancer cells hampers the design of effective therapies and yet it is poorly reproduced in experimental models. A recent report by Eirew at al. provides an in-depth analysis of genetic heterogeneity of breast tumor xenografts and shows that changes in clonal diversity might not be stochastic.
Medical subject headings
- Breast Neoplasms
- Clone Cells
- Genome, Human
- Single-Cell Analysis
- Xenograft Model Antitumor Assays