Generating iPSCs: translating cell reprogramming science into scalable and robust biomanufacturing strategies.

Silva, Marli; Daheron, Laurence; Hurley, Hannah; Bure, Kim; Barker, Richard; Carr, Andrew J; Williams, David; Kim, Hae-Won et al. · Cell Stem Cell · 2015

basic_science · Level V

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Abstract

Induced pluripotent stem cells (iPSCs) have the potential to transform drug discovery and healthcare in the 21(st) century. However, successful commercialization will require standardized manufacturing platforms. Here we highlight the need to define standardized practices for iPSC generation and processing and discuss current challenges to the robust manufacture of iPSC products.

Medical subject headings