Human Influenza A Virus-Specific CD8+ T-Cell Response Is Long-lived.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25583167.
- Also identified by DOI 10.1093/infdis/jiv018 and PMC identifier 4542594.
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Abstract
Animal and human studies have demonstrated the importance of influenza A virus (IAV)-specific CD8(+) cytotoxic T lymphocytes (CTLs) in heterosubtypic cross-protective immunity. Using peripheral blood mononuclear cells obtained intermittently from healthy HLA-typed blood donors between 1999 and 2012, we were able to demonstrate that IAV-specific CTLs are long-lived. Intercurrent IAV infections transiently increase the frequency of functionally distinct subsets of IAV-specific CTLs, in particular effector and effector memory T cells.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Immunologic Memory
- Influenza, Human
- Alphainfluenzavirus