Novel recurrently mutated genes in African American colon cancers.
prospective_cohort · Level II
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- Record sourced from PubMed, PMID 25583493.
- Also identified by DOI 10.1073/pnas.1417064112 and PMC identifier 4313860.
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Abstract
We used whole-exome and targeted sequencing to characterize somatic mutations in 103 colorectal cancers (CRC) from African Americans, identifying 20 new genes as significantly mutated in CRC. Resequencing 129 Caucasian derived CRCs confirmed a 15-gene set as a preferential target for mutations in African American CRCs. Two predominant genes, ephrin type A receptor 6 (EPHA6) and folliculin (FLCN), with mutations exclusive to African American CRCs, are by genetic and biological criteria highly likely African American CRC driver genes. These previously unsuspected differences in the mutational landscapes of CRCs arising among individuals of different ethnicities have potential to impact on broader disparities in cancer behaviors.
Medical subject headings
- Black or African American
- Colonic Neoplasms
- Mutation
- Proto-Oncogene Proteins
- Receptor, EphA6
- Tumor Suppressor Proteins