Dawn of the Epi-LncRNAs: new path from Myheart.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 25593274.
- Also identified by DOI 10.1161/CIRCRESAHA.114.305490 and PMC identifier 4313530.
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Abstract
Myheart is a cardiac specific long-noncoding (lnc) RNA with targeted modulation of chromatin modifying SWI/SNF complex via direct interaction with Brg1. Genetic induction of Myheart in mouse heart has a significant protective effect against the pathogenesis of heart failure. LncRNAs are emerging epigenetic regulators with potentially important roles in cardiac development and diseases.
Medical subject headings
- Cardiomegaly
- Myosin Heavy Chains
- RNA, Long Noncoding