Enhanced activity of cyclic transporter sequences driven by phase behavior of peptide-lipid complexes.
basic_science · Level V
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- Record sourced from PubMed, PMID 25593589.
- Also identified by PMC identifier 4293126.
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Abstract
We demonstrate that recent observed increases in cell permeation activity of cyclic peptides via transporter sequences is due to the underlying phase behavior of peptide-lipid complexes and its relation to the topological requirement of membrane permeation. We also show how these effects can be amplified by incorporating hydrophobicity in these sequences.